如題...

IE home page locking:
http://www.geocities.com/kilian0072002/IEHijack2.htm#2

Or hide the IE Internet Options menu:
http://www.geocities.com/kilian0072002/IEHijack1.htm#2.1

NOTE: Both methods only prevent other users sitting in front of the PC from resetting the home page but does NOT prevent malicious scripts and ActiveX in websites from doing so.